Pathological airway remodelling in inflammation
نویسندگان
چکیده
منابع مشابه
Inflammation and remodelling in the ageing airway.
WHAT WE NEED TO KNOW: What changes occur in atopic and non-atopic airway inflammation in asthma with increasing age? What is the relationship between wound healing and airway remodelling in older subjects? What is the response to anti-inflammatory therapy in older subjects? What is the basis of the "overlap syndrome" with chronic obstructive pulmonary disease in older people with asthma, in who...
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Acetylcholine is the predominant parasympathetic neurotransmitter in the airways that regulates bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine regulates additional functions in the airways, including inflammation and remodelling during inflammatory airway diseases. Moreover, it has become apparent that acetylcholine is synthesized by nonneuronal cells and ti...
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To study the physiopathology and significance of asymptomatic airway hyperresponsiveness (AHR), the clinical and bronchial immunohistological parameters were evaluated in subjects with asymptomatic and symptomatic AHR. Asymptomatic subjects with AHR (eight females/two males, no respiratory symptoms, provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one ...
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The hallmark pathological features of asthma include airway eosinophilic inflammation and structural changes (remodelling) which are associated with an irreversible loss in lung function that tracks from childhood to adulthood. In parallel with changes in function, pathological abnormalities occur early, during the pre-school years, are established by school age and subsequently remain (even th...
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Pulmonary disease is the most important cause of morbidity and mortality in cystic fibrosis (CF). Most patients with CF die from respiratory failure with extensive airway destruction. Airway remodelling, defined as structural airway wall changes, begins early in life in CF but the sequence of remodelling events in the disease process is poorly understood. Airway remodelling in CF has traditiona...
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ژورنال
عنوان ژورنال: The Clinical Respiratory Journal
سال: 2010
ISSN: 1752-6981,1752-699X
DOI: 10.1111/j.1752-699x.2010.00190.x